UAMS.EDU

Faculty Member – E. Kim Fifer

E. Kim Fifer, Ph.D.

Professor

Office: Biomed II, Room 140-2F
Phone: 501-686-8134
FAX: 501-526-6599
E-mail: EKFifer@uams.edu

Education & Training

B.S., (Pharmacy), 1975; University of Arkansas for Medical Sciences
Ph.D., 1983; University of Mississippi

Teaching Responsibilities

Professional Pharmacy:
Pharmaceutical Biochemistry, PhSci 3215
Principles of Drug Actions, PhSci 3224
Medicinal and Natural Products Chemistry, PhSci 4254

Graduate Program:
Medicinal Chemistry for Graduate Students, PHSC 5013

Research Interests

My research interests involve the application of organic chemistry to the solution of biological problems. Ongoing projects include the design and synthesis of potential antineoplastic agents and the development of prodrugs with immunomodulatory activity.

Honors & Awards

Recipient of one of the Inventors of the Year awards (1995)

Teacher of the Year in Biopharmaceutical Sciences (1997)

Recent Publications

Zhou, Xiang; Handie, Andronica; Salari, Hamid; Fifer, E. Kim; Breen, Philip J.; Compadre, Cesar M. High Performance Liquid Chromatography Determination of Residue Levels on Chicken Carcasses Treated with Cetylpyridinium Chloride. J. Chromatography B 1999, 728, 273-277

Gilbert, Kathleen M; Wahid, Rahnuma; Fecher, Nuria Portabella; Freeman, James P.; Fifer, E. Kim Potential Clinical Use of Butyric Acid Derivatives to Induce Antigen-Specific T Cell Inactivation. J. Pharmacol. Exptl. Therap. 2000, 294, 1146-1153.

Lattin, Danny L. and Fifer, E. Kim. Cholinergic Drugs, In: “Principles of Medicinal Chemistry”, 5th ed.; Chapter 10 Foy, W.O., Lemke, T.L. and Williams, D.A., Ed.; Lippincot, Williams and Wilkins, Philadelphia, 200

Gilbert, Kathleen M.; Boger, Susan, Fifer, E. Kim Butyric Acid Derivative Induces Allospecific T Cell Anergy and Prevents Graft-Versus-Host Disease, Immunopharmacol. Immunotoxicol. 2003, 25, 13-17.

Soderberg, L.S.F.; Boger, S.; Fifer, E.K.; Gilbert, K.M. Macrophage Production of Inflammatory Mediators is Potently Inhibited by a Butyric Acid Derivative Demonstrated to Inactivate Antigen-Stimulated T Cells, International Immunopharmacol. 2004, 4(9), 1231-1239.

Recent Patents

Lattin, D.L.; Breen, P.J.; Compadre, C.M.; Fifer, E.K.; Slavick, M.F.; Salari, H.; Engler, P.V. Use of Quaternary Ammonium Compounds to Remove Salmonella Contamination from Meat Products, U.S. Patent Number 5,366,983; November 22, 1994.

Compadre, C.M.; Breen, P.; Salari, H.; Fifer, E.K. Lattin, D.L.; Slavik, M.; Li, Y Improved Method for the Broad Spectrum Prevention and Removal of Microbial Contamination of Poultry and Meat Products by Quaternary Ammonium Compounds, U.S. Patent Number 5,855,940; January 5, 1999.

Compadre, C.M.; Breen, P.; Salari, H.; Fifer, E.K. Lattin, D.L.; Slavik, M.; Li, Y, O’brien, T, Improved Method for the Broad Spectrum Prevention and Removal of Microbial Contamination of Poultry and Meat Products by Quaternary Ammonium Compounds, Continuation in Part, U.S. Patent Number 6,039,992; March 21, 2000.

Gilbert, K. and Fifer, E.K. Derivatives of Butyric Acid and Uses Thereof: U.S. Patent Number 6,407,107 B1, June 18, 2002.

Gilbert, K. and Fifer, E.K. Derivatives of Butyric Acid and Uses Thereof: U.S. Patent Number 6,664,394, B2, December 16, 2003.