Faculty Member – E. Kim Fifer

E. Kim Fifer, Ph.D. 

Professor

Department of Pharmaceutical Sciences
Office: Biomed II, Room 140-2
Phone: 501-686-8134
E-mail: ekfifer@uams.edu

Education & Training

B.S. (Pharmacy), 1975; University of Arkansas for Medical Sciences
Residency (Hospital Pharmacy), 1976 University of Arkansas for Medical Sciences
Ph.D. (Medicinal Chemistry), 1983; University of Mississippi
Post-doctoral Fellowship, 1983-1986, National Center for Toxicological Research (Biochemical Toxicology)

Teaching Responsibilities

Professional Pharmacy:
Biological and Cellular Chemistry, PhSci 7102
Principles of Drug Actions, PhSci 7103
Medicinal and Natural Products Chemistry, PhSci 7203
Molecular Biology & Biotechnology, PhSci 7204

Graduate School:
Medicinal Chemistry for Graduate Students, PHSC 5101

Research Interests

Application of organic chemistry to the solution of biological problems – the design and synthesis of potential antineoplastic agents and chemical mechanisms of drug toxicity.

Honors & Awards

Inventor of the Year awards (1995)
Graduating Class of 1997 – Most Outstanding Professor (Dept. of Biopharmaceutical Sciences)
Graduating Class of 2014 – Most Outstanding Professor (Dept. of Pharmaceutical Sciences)
Teacher of the Year 2013-2014, Selected by the Student Body

Memberships

American Chemical Society (1977-present)
Division of Medicinal Chemistry
Division of Organic Chemistry
American Association of Colleges of Pharmacy (1986- present)
Arkansas Pharmacists Association
Kappa Psi Pharmaceutical Fraternity
Rho Chi Pharmaceutical Honor Society

Publications

Shaik, Zabeena P.; Fifer, E. Kim and Nowak, Grażyna, Akt activation improves oxidative phosphorylation in renal proximal tubular cells following nephrotoxicant injury, Am. J. Physiol. Renal Physiol. 2008, 294, 423-432. (12/12/2007, doi: 10.1152/ajprena1.00463.2007).

Vadlapatla, Rajesh; Fifer, E. Kim; Alexander, Kenneth S.; Kim, Cherng-ju, Drug-Organic Electrolyte Complexes as Controlled Release Systems, Drug Develop. Indust. Pharm., 2008, iFirst, 1-11, ISSN: 0363-9045 print / 1520-5762 online. Drug Development and Industrial Pharmacy 2009, 35(1), 1-11.

Vadlapatla, Rajesh; Fifer, E. Kim; Alexander, Kenneth S.; Kim, Cherng-ju, In-situ Complex Systems of Drug and Organic Electrolyte for Extended Release Tablets, The Open Drug Delivery J. 2010, 4, 21-29.

Agarwal, Rakhee; Macmillan-Crow, Lee Ann; Rafferty, Tonya; Saba, Hamida; Roberts, Dean; Fifer, E. Kim; James, Laura P.; Hinson, Jack A., Acetaminophen-Induced Hepatotoxicity in Mice Occurs with Inhibition of Activity and Nitration of Mitochondrial Manganese Superoxide Dismutase”, J. Pharmacol. Exptl. Res. 2011, 337, 110-116. (Fast Forward: DDOI:10.1123/jpdg.110.176321)

Chimalakonda, Krishna C.; Moran, Cindy L.; Kennedy, Paul D.; Endres, Gregory W.; Endres, Adam Uzieblo; Dobrowolski, Paul J.; Fifer, E. Kim; Lapoint, Jeff, Nelson; Lewis S.; Hoffman, Robert S.; James, Laura P.; Radominska-Pandya, Anna; Moran, Jeffery H., Solid-phase Extraction and Quantitative Measurement of Omega and Omega-1 Metabolites of JWH-018 and JWH-073 in Human Urine. Anal. Chem. 2011, 83(11), 4228-4236.

Gurley Bill J; Fifer Espero Kim; Gardner Zoe, Pharmacokinetic Herb-Drug Interactions (Part 2); Drug Interactions Involving Popular Botanical Dietary Supplements and Their Clinical Relevance, Planta Medica 2012, 78(13), 1490-1414.

Peng, Can; Kimbrell, Matthew R.; Tian, Chengju; Pack, Thomas F.; Crooks, Peter A.; Fifer, E. Kim; and Papke, Roger L., Multiple Modes of  a7 nAChR Noncompetitive Antagonism of Control Agonist-Evoked and Allosterically Enhanced Currents. Mol. Pharmacol. 2013, 84, 459-475.

Wan, Anqi; Penthala, Narsimha Reddy; Fifer, E. Kim; Parkin, Sean; Crooks, Peter A., Comparison of the Crystal Structures of 4,4′-Bis[3-(4-methylpiperidin-1-yl)prop-1-yn-1-yl]-1,1′-biphenyl and 4,4′-Bis[3-(2,2,6,6-tetramethylpiperidin-1-yl)prop-1-yn-1-yl]-1,1′-biphenyl. Acta Crystallographica, Section E: Crystallographic Communications 2015, 71(10), 1132-1135.

Wan, Anqi; Penthala, Narsimha Reddy; Fifer, E. Kim; Parkin, Sean; Crooks, Peter A. Comparison Crystal Structure Conformations of Two Structurally Related Biphenyl Analogues: 4,4′-Bis[3-(pyrrolidin-1-yl)prop-1-yn-1-yl]-1,1′-biphenyl and 4,4′-Bis{3-[(S)-2-methylpyrrolidin-1-yl]prop-1-yn-1-yl}-1,1′-biphenyl, Acta Crystallographica, Section E: Crystallographic Communications 2015, 71(10), 1147-1150.

Hartman, Jessica H.; Letzig, Lynda G.; Roberts, Dean W.; James, Laura P.; Fifer, E. Kim; Miller, Grover P., Cooperativity in CYP2E1 Metabolism of Acetaminophen and Styrene Mixtures, Biochemical Pharmacology (Amsterdam, Netherlands), 2015, 97(3), 341-349.

Gupta, Prem K.; Barone, Gary; Gurley, Bill J.; Fifer, E. Kim; Hendrickson, Howard P., Hydrastine Pharmacokinetics and Metabolism after a Single Oral Dose of Goldenseal (Hydrastis Canadensis) to Humans, Drug Metabolism & Disposition 2015, 43(4), 534-552.

Gurley Bill J; Fifer Kim E.; Gardner, Zoe, Phytochemical Modulators of Human Drug Metabolism: Drug Interactions with Fruits, Vegetables, and Botanical Dietary Supplements, In: “Encyclopedia of Drug Metabolism and Interactions,” Vol 6, 1st ed.; John Wiley and Sons, Hoboken, NJ, 2012.

Fifer, E. Kim. Cholinergic Drugs, In: “Foy’s Principles of Medicinal Chemistry”, 7th ed.; Williams, D.A. and Lemke, T.L., Ed.; Lippincot, Williams and Wilkins, Philadelphia, 2013, Chapter 9.

Patents
Lattin, D.L.; Breen, P.J.; Compadre, C.M.; Fifer, E.K.; Slavick, M.F.; Salari, H.; Engler, P.V. Use of Quaternary Ammonium Compounds to Remove Salmonella Contamination from Meat Products, U.S. Patent Number 5,366,983; November 22, 1994.

Compadre, C.M.; Breen, P.; Salari, H.; Fifer, E.K. Lattin, D.L.; Slavik, M.; Li, Y Improved Method for the Broad Spectrum Prevention and Removal of Microbial Contamination of Poultry and Meat Products by Quaternary Ammonium Compounds, U.S. Patent Number 5,855,940; January 5, 1999.

Compadre, C.M.; Breen, P.; Salari, H.; Fifer, E.K. Lattin, D.L.; Slavik, M.; Li, Y, O’brien, T, Improved Method for the Broad Spectrum Prevention and Removal of Microbial Contamination of Poultry and Meat Products by Quaternary Ammonium Compounds, Continuation in Part, U.S. Patent Number 6,039,992; March 21, 2000.

Compadre, C.M.; Breen, P.; Salari, H.; Fifer, E.K. Lattin, D.L.; Slavik, M.; Li, Y, O’brien, T, Improved Method for the Broad Spectrum Prevention and Removal of Microbial Contamination of Poultry and Meat Products by Quaternary Ammonium Compounds, Continuation in Part, Foreign Patent Co-Operation Treaty, Pending, April 11, 1997.

Gilbert, K. and Fifer, E.K. Derivatives of Butyric Acid and Uses Thereof: U.S. Patent Number 6,407,107 B1, June 18, 2002.

Gilbert, K. and Fifer, E.K. Derivatives of Butyric Acid and Uses Thereof: U.S. Patent Number 6,664,394, B2, December 16, 2003.

Compadre, C.M.; Breen, P.; Salari, H.; Fifer, E.K. Lattin, D.L.; Slavik, M.; Li, Y; O’brien, T.; Waldroup, A.; Berg T. Concentrated, Non-Foaming Solution of Quarternary Ammonium Compounds and Methods of Use: U.S. Patent Number 6,864,269 B2, March 13, 2005

Compadre, C.M.; Breen, P.; Salari, H.; Fifer, E.K., Lattin, D.L.; Slavik, M.; Li, Y Broad Spectrum Prevention and Removal of Microbial Contamination of Food by Quaternary Ammonium Compounds. European Patent 05017265.9-2114, October 17, 2005.

Gilbert, K. and Fifer, E.K. Derivatives of Butyric Acid and Uses Thereof: U.S. Patent Number 7,034,020 B2, B2, April 25, 2006.

Compadre, C.M.; Breen, P.; Salari, H.; Fifer, E.K. Lattin, D.L.; Slavik, M.; Li, Y; O’brien, T.; Waldroup, A.; Berg T. Concentrated, Non-Foaming Solution of Quarternary Ammonium Compounds and Methods of Use: U.S. Patent Number 7,541,045 B2, June 2, 2009

Compadre, C.M.; Breen, P.; Salari, H.; Fifer, E.K. Lattin, D.L.; Slavik, M.; Li, Y; O’brien, T.; Waldroup, A.; Berg T. Concentrated, Non-Foaming Solution of Quarternary Ammonium Compounds and Methods of Use: U.S. Patent Number 8,323,673, December 4, 2012