Rupak Pathak, PhD

Assistant Professor

Department of Pharmaceutical Sciences
Phone: (501) 603-1472
Fax: (501) 686-6057
Office: BioMed I, Room: B238G, Slot: 522-3
Email: rpathak@uams.edu

Education & Training

  • Dr. Pathak received his PhD in Radiation Biology from Kalyani University (Kalyani, West Bengal, India). He served as Assistant Professor in the Radiobiology Department of Manipal University (Manipal, Mangalore, Karnataka, India). He received postdoctoral training at the Armed Forces Radiobiology Research Institute (Bethesda, MD, USA).
  • Dr. Pathak was a Research Instructor of Pharmaceutical Sciences at the University of Arkansas for Medical Sciences (UAMS), faculty member of the Division of Radiation Health in the College of Pharmacy.
  • Dr. Pathak’s research was focused on low- and high-LET radiation induced cytogenetic alterations in mammalian cells and understanding the molecular mechanisms of cell death during his PhD He worked in the field of radiation bio-dosimetry and radiation countermeasure during his post-doctoral training. His current research interest is radiation-induced normal tissue injury particularly radiation-induced endothelial dysfunction and genomic instability using FISH-based molecular techniques. He has extensive training and practical experience working with transgenic mouse models.  His one of the major research goals is to develop radiation countermeasures that can be used in the event of accidental or incidental radiation mass casualty and find out the molecular basis of radiation protection.

Publications

  • R. Pathak, A. K. Cheema, S. M. Boca, K. J. Krager, M. Hauer-Jensen, N. Aykin-Burns, 2015, Modulation of Radiation Response by the Tetrahydrobiopterin Pathway, Antioxidants, 4(1), 68-81. (Review) (http://www.mdpi.com/2076-3921/4/1/68)
  • Y. You, R. Wen, R. Pathak, A. Li, W. Li, D. St Clair, M. Hauer-Jensen, D. Zhou, Y. Liang, 2014, Latexin sensitizes leukemogenic cells to gamma-irradiation-induced cell cycle arrest and cell death through Rps3 pathway. Cell Death Dis. 5:e1493. [PMID: 25341047; PMCID: PMC4237263]
  • R. Pathak, L. Shao, S. M. Chafekar, W. Feng, U. Ponnappan, L.M. Fink, D. Zhou,
    M. Hauer-Jensen, 2014, IKKβ regulates thrombomodulin in a Klf2-dependent manner. J Thromb Haemost. 12(9):1533-44 [PMID: 25039491; PMCID: PMC4163124]
  • J. Wray, E. A. Williamson, S. B. Singh, Y. Wu, C. R. Cogle, D. M. Weinstock, Y. Zhang, S-H. Lee, D. Zhou, L. Shao, M. Hauer-Jensen, R. Pathak, V. Klimek, J. A. Nickoloff, and R. Hromas, 2013, PARP1 is required for chromosomal translocations. Blood, 121, 4359-4365[PMCID: PMC3663429]
  • R. Pathak, S. Pawar, Q. Fu, P. K. Gupta, M. Berbee, S. Garg, V. Sridharan, W. Wang, B. Prabath, K. Krager, M. Boerma, S. Ghosh, A. Cheema, H. Hendrickson, N. Aykin-Burns, M. Hauer-Jensen, 2013, Characterization of transgenic Gfrp knock-in mice: Implications for tetrahydrobiopterin in modulation of normal tissue radiation responses. Antioxid Redox Signal. 20, 1436-1446. [PMCID: PMC3936502]


CV Pathak, Rupak