Faculty Member – Snehalata Pawar

Snehalata Pawar, PhD 

Assistant Professor, Division of Radiation Health Pharmaceutical Sciences

Office: Biomed-II, 408-2 (office)
E-mail address: SApawar@uams.edu
Phone: 501-686-5784 (office)
Fax: 501-686-6057

Education & Training

  • 1987-1990 B. Sc. (Microbiology), University of Bombay, Mumbai, India
  • 1990-1992 M. Sc. (Biochemistry), Maharaja Sayajirao University, Baroda, India
  • 1993-1999 Ph. D. (Biochemistry), University of Pune, Pune, India

Teaching Responsibilities 

2011 – present Course Instructor, Biological & Cellular Chemistry (PhSc 7102)
Pharmacy core curriculum, P1 year, topics taught-Lipid metabolism, Amino acid metabolism, Digestion & absorption of a meal & Micronutrients (12 lecture hours)

2017 Radiation Biology (PhSc 6112)                                                                                                                   Course Instructor, topics taught- Acute toxicity of IR to the gastrointestinal tract/GI syndrome- Role of inflammation/oxidative/nitrosative stress in promoting tissue injury, apoptosis and DNA damage response in intestinal epithelium, various assays to determine the GI injury, use of radiation countermeasures to alleviate GI syndrome.

Honors & Awards

  • 1993-1995 Junior Research Fellow, Council of Scientific and Industrial Research (CSIR) Fellowship, New Delhi, India
  • 1995-1998 Senior Research Fellow, CSIR Fellowship, New Delhi, India.
  • 2008 Travel Award ($1000), 8th Annual Fellows & Young Investigators Colloquium, Ocean City, MD

Memberships 

  • 1998 Society of Biological Chemists, India
  • 2009-present Radiation Research Society
  • 2009-present Association of American Colleges of Pharmacy
  • 2012-present Society for Redox Biology and Medicine
  • 2013-present International Cytokine and Interferon Research Society
  • 2014-present American Association of Cancer Research
  • 2014-present American Association for Advancement of Science
  • 2016-present Shock Society

Recent Publications

1. Pawar SA #, Roy-Sarkar T #, Kuppuswamy B, Wang J, Zhang Y, Dowdy S, Huang A,
Sharan S and Sterneck E. C/EBPδ targets cyclin D1 for proteasome-mediated
degradation via induction of CDC27/APC3 expression. Proc. Natl. Acad. Sci. USA.
107:9210-5, 2010.
2. Roysarkar T, Sharan S, Wang J, Pawar SA, Cantwell CA, Johnson PF, Morrison DK,
Wang JM, Sterneck E. Identification of a Src tyrosine kinase/SIAH2 E3 ubiquitin ligase
pathway that regulates C/EBPδ expression and contributes to transformation of
breast tumor cells. Molecular and Cellular Biology, 32:320-332, 2012.
3. Geiger H #, Pawar SA #, Kerschen EJ #, Nattamai KJ #, Hernandez I, Liang H-P,
Fernández JA, Cancelas JA, Ryan MA, Kustikova O, Schambach A, Fu Q, Wang J, Fink
LM, Petersen K-U, Zhou, D, Griffin JF, Baum C, Weiler H, Hauer-Jensen M.
Pharmacological targeting of the thrombomodulin–protein C pathway mitigates
radiation toxicity. Nature Medicine, 18:1123-1129, 2012.
4. Pathak R, Pawar SA, Gupta, P., Fu, Q., Berbée, M., Garg, S., Sridharan V., Wang, W., Biju,
P.G., Kragerly, K., Boerma, M., Ghosh, S.P., Cheema, A.K., Hendrickson, H. P., Aykin-
Burns, N. and Hauer-Jensen, M. Characterization of transgenic Gfrp knock-in mice:
Implications for BH4 in modulation of radiation response. Antioxidants Redox
Signaling 20:1436-46, 2014.
5. Pawar SA*#, Shao L #, Chang J, Wang W, Pathak R, Wang J, Zhu X, Boerma M, Sterneck
E, Zhou, D and Hauer-Jensen M. C/EBPδ deficiency sensitizes mice to ionizing radiation-
induced hematopoietic and intestinal injury. PLOS ONE 9:e94967, 2014.
6. Banerjee S, Aykin-Burns N, Krager KJ, Shah SK, Melnyk SB, Hauer-Jensen M, Pawar SA*.
Loss of C/EBPδ enhances IR-induced cell death by promoting oxidative stress and
mitochondrial dysfunction. Free Radical Biology and Medicine, 99:296-307, 2016.
http://dx.doi.org/10.1016/j.freeradbiomed.2016.08.022

Curriculum Vitae