March 21, 2019

John Seng, PhD

John Seng, PhD

Assistant Professor of Pharmaceutical Sciences
Member, Division of Radiation Health

Phone: 501.686.6827
Office: BioMed II

Education & Training

PhD – Interdisciplinary Toxicology, University of Arkansas at Little Rock
Dissertation: “Characterization of Selective Cytochrome P-450 Isozymes in Rat Testes”

MS – Microbiology, Northeast Louisiana University
Thesis: “The Effects of N-butyl-4-hydroxybutyl Nitrosamine and Trans-4-aminomethylcyclohexane Carboxylic Acid on Anaerobic Bacteria Isolated from Rat Intestine”

Clinical Research Certificate, UAMS

Project Management Masters Certification, American Project Management

Additional training:

  • Clinical Research Specialist, UAMS
  • Clinical Research Project/Program Management Conference, Society of Clinical Research Associate
  • Ophthalmic Drug Development & Delivery Summit, Pharmaceutical Education Associates
  • Clinical Biomarker Summit, Cambridge Healthtech Institute
  • Workshop on Juvenile Animal Studies: Testing Strategies & Design, ILSI Health & Environmental Sciences Institute
  • Study Director Training: Focus on Data Evaluation, American College of Toxicology
  • Regulatory Update: US FDA & US EPA, American College of Toxicology
  • Incorporation of Pharmacokinetic & Pharmacodynamic Data into Risk Assessment, Society of Toxicology
  • Understanding the Regulator’s Approach to Reproductive Toxicology Data, A Henry Stewart Briefing on the Presentation & Interpretation of Data

Teaching Responsibilities

Good Laboratory Practices (GLP), Graduate Certificate in Regulatory Sciences, UAMS College of Public Health

Clinical Practice

Designed and managed numerous clinical studies conducted at UAMS.

Research & Scholarly Interests

Providing expertise in preclinical GLP radiation mitigation study design, project management, and data analysis for regulatory submission.

Provide scientific and business direction for laboratories which conducts general toxicology and vaccine studies for the pharmaceutical and chemical industries for submission to governmental agencies. Range of study types includes acute through chronic/carcinogenesis via oral, dermal, nasal, ocular and injection routes of administration. Responsible for the scientific, personnel, regulatory guideline compliance, and budgetary aspects for the laboratory.

Honors & Awards

Executive Bonus Plan, 2007 through 2009 – Charles River Laboratories

Best Paper in the Field of Risk Assessment, “Use of Dietary Control to Regulate Body Weight and Variability in Male B6C3F1 Mice Used for the Bioassay of Chloral Hydrate,” 2001 – National Society of Toxicology

Best Paper in the Field of Risk Assessment, “Chronic Bioassays for Liver Tumors in B6C3F1 Mice Using Idealized Weight Curves Produced by Controlled Feeding,” 1999 – National Society of Toxicology

Best Paper in the Field of Food Safety, “Molecular Players in Increased Thioacetamide-Hepatic Injury and Decreased Mortality following Diet Restrictions,” 1999 – National Society of Toxicology

On the Spot Award, 1996 – FDA

Outstanding Graduate Student Research Award, 1993 – University of Arkansas


Radiation Research Society (RRS)

Reports & Publications

Technical Reports
“Advanced Development of SOM230 as a Radiation Mitigator.” Contract HHSO100201100045C. U.S. Department of Health and Human Services, Biomedical Advanced Research and Development Authority (BARDA, 2017)

National Toxicology Program (NTP) (2002). Toxicology and Carcinogenesis Study of Chloral Hydrate (Ad libitum and dietary controlled) (CAS NO. 302-17-0) in Male B6C3F1 Mice (Gavage Study). Technical Report Series No. 503. NIH Publication No.03-4437. U.S. Department of Health and Human Services, Public Health Service, National Institutes of Health, Research Triangle Park, NC

Yan Yu, Hong Jin, Daniel Holder, Josef S. Ozer, Stephanie Villarreal, Paul Shughrue, Shu Shi, David J. Figueroa, Holly Clouse, Ming Su, Nagaraja Muniappa, Sean P. Troth, Wendy Bailey, John Seng, Amy G. Aslamkhan, Douglas Thudium, Frank D. Sistare, and David L. Gerhold (2010) Biomarkers of Kidney Tubule Injury: Urinary Trefoil Factor 3 and Albumin. Nature Biotechnology, 28: 470 – 477

Christian, M.S., Sharper, V.A., Hoberman, A.M., Seng, J.E., Fu, L., Covell, D., Diener, R.M., Bitler, C.M., and Crea, R. The Toxicity Profile of Hydrolyzed Aqueous Olive Pulp Extract. Drug and Chemical Toxicology, 27: 309-330.

Leakey, Julian E., Seng, John E., and Allaben, William T. Influence of Body Weight, Diet, and Stress on Aging, Survival and Pathological Endpoints in Rodents: Implications for Toxicity Testing and Risk Assessment. Regulatory Research Perspectives, 4: 1-29.

Seng, John E., Agraval, Nalini, Horsley, Elizabeth M.T., Sherer, Erin, Xia, Shijun, Leakey, Tatiana I., Allaben, William T., and Leakey, Julian E.A. Toxicokinetics of Chloral Hydrate in Ad Libitum-Fed, Dietary-Controlled, and Calorically Restricted Male B6C3F1 mice following Short-Term Exposure. Toxicology and Applied Pharmacology, 193: 281-292.


Curriculum Vitae