March 21, 2019

Narsimha Reddy Penthala, PhD

Narsimha Reddy Penthala, PhD

Research Instructor

Pharmaceutical Sciences
E-mail address:
Phone: 501-603 1357
Office: Biomed II Room 112-2


Education & Training

  • Dr. Penthala received his Ph. D in Synthetic Organic Chemistry from National Institute of Technology (Warangal, Telangana, India) and worked as Scientist in Chemical Research Division, Aurobindo Pharma Ltd, R&D.
  • Dr. Penthala received his post doctoral training at University of Kentucky, Lexington, KY, USA and University of Arkansas for Medical Sciences (UAMS), USA

Teaching Responsibilities 

Current Good Manufacturing Practice (cGMP; PHS 640) class spring semester
cGMP guidelines on synthesis of drug molecules

Research & Scholarly Interests

Our research group focuses on the design, synthesis, and structure-activity relationship study of novel bio-film formation inhibitors and radio sensitizing agents. We are also focusing on the design and synthesis of natural product based Combretastatin A-4 analogs as anti-cancer agents and also sesquiterpene lactone Parthenolide analogs Melampomagnolide B, Micheliolide prodrugs and co-drugs as anti-leukemic agents. Our research group is also interested in the eco-friendly process development of Active Pharma Ingredients (API) , in cost effective synthetic methodologies including Microwave Irradiation techniques in order to prepare the library of compounds in short time with good quality and yield.

Honors & Awards

Received the award from Elsevier publishers for the most cited article (2005-2008), “Sulfamic acid: a novel and efficient catalyst for the synthesis of aryl-14 H-dibenzo[a.j]xanthenes in conventional heating and microwave irradiation”. Tetrahedron Letters, 46 (50) 2005, 8691-8693. .


  • American Association of pharmaceutical Scientists (AAPS)-Member (Since 2008)
  • Planning committee chair AAPS-UAMS student chapter (2012-2013)
  • American Chemical Society-Member (2014)
  • Sigma Xi, The Scientific Research Society- Member (2010)


  • Narsimha Reddy Penthala, Shobanbabu Bommagani, Jaishankar Yadlapalli, Peter A. Crooks, A novel and efficient tributyltin azide-mediated synthesis of 1H-tetrazolylstilbenes from cyanostilbenes, Tetrahedron Letters, 2016, Volume 57, Issue 16, , Pages 1807-1810.
  • Narsimha Reddy Penthala, Amit Ketkar, Rajashekar Konjeti, Michael. L. Freeman, Robert. L. Eoff, Ramesh Balusu and Peter A. Crooks “Design, synthesis and evaluation of novel 2-methyl-N-benzyl indole derivatives as anti-tumor agents that target nucleophosmin 1 (NPM1)” Bio-Organic and Medicinal Chemistry, 2015, 23(22), 15 7226-7233. PMID: 26602084.
  • Venumadhav Janganati, Jessica Ponder, Craig T. Jordan, Michael J. Borrelli, Narsimha Reddy Penthala, and Peter A. Crooks, Dimers of melampomagnolide B exhibit potent anticancer activity against hematological and solid tumor cells, Journal of Medicinal Chemistry, 2015, 58(22), 8896-906. PMID: 26540463.
  • Nikhil R. Madadi, Narsimha R. Penthala, Kevin Howka, Amit Ketkar, Robert L. Eoff, Michael J. Borrelli, and Peter A. Crooks, Synthesis and biological evaluation of novel 4,5-disubstituted 2H-1,2,3-triazoles as cis-constrained analogues of combretastatin A-4, European Journal of Medicinal Chemistry, 2015, 103, 123-132.
  • Narsimha R. Penthala, Leena Madhukuri, Shraddha Thakkar, Nikhil Reddy Madadi. Gauri Lamture, Robert Eoff, and Peter A. Crooks, Synthesis and anti-cancer screening of novel heterocyclic-(2H)-1,2,3-triazoles as potential anti-cancer agents; Med. Chem. Commun., 2015, 6, 1535-1543.

Curriculum Vitae